![]() The one unusual aspect of their symptoms is that for 18 of these 17 men, their rash started in the anal genital area, and then spread to the rest of the body. Many reported fatigue, chills, swollen, lymph nodes, all common for monkeypox. All but one of the men had a rash across their body. ![]() "Many of these symptoms are consistent with what we would expect to see with monkeypox. At this point, there is currently no evidence that additional treatment is needed with Paxlovid, or other therapies and cases where COVID 19 rebound is suspected."ġ0 What Symptoms of Monkeypox Are Being Reported? Shutterstock If I'm someone at low risk of experiencing serious illness, and I take Paxlovid, and rather than recover within the seven to 10 days, I have a rebound, might then that mean I would be in isolation for an additional seven to 10 days, making my course anywhere from 12 to 15 days of isolation, as opposed to what we currently do. This is a very important point, and this is really the second issue at concern. It's recommended that if someone develops symptoms or has a positive test after a course of treatment with Paxlovid, that they begin the isolation protocol all over again, to keep them from infecting others. First, it's not that people with rebound infection may experience serious disease, but rather they could unknowingly transmit the virus to others in their rebound period. "So with this situation there really are two main concerns. Ideally, any waves we could see won't be followed by a significant amount of hospitalizations or deaths, as has so far been the case with South Africa, but it just goes to show how quickly this virus can adapt and overcome the protection against infection."Ĩ COVID Rebound After Paxlovid Treatment Shutterstock So as always, we'll have to see what actually happens in the days ahead. In fact, there's some evidence of that playing out in countries like Portugal and Switzerland, and we're seeing these sublineages grow in places like the UK and the US as well. We don't know where this ultimately will take us. "Again, I come back to that issue of the battle between our human immune system and the virus and its ability to evolve. "A growing body of data suggesting that BA.4 and BA.5 can readily evade protection against infection, particularly among unvaccinated individuals previously infected by BA.1, indicates that growth of these sublineages could prompt notable case increase into a number of different countries," says Dr. 4 What's Happening With BA.4 and BA.5? Shutterstock
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